We're getting ready to head to Miami for the 6th American Society of Pain and Neuroscience ASPN Annual Conference! Come get hands on experience with Nevro’s products including HFX iQ™ and Nevro1™ at Booth 157! #ASPN2024 #Nevro1 #SIJoint #SIJointFusion #NevroHFX #HFXiQ
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Going to #ASPN2024? We’ll be there, and Tim Deer, MD will be sharing the latest 3-year results on the Mild Procedure from the MOTION Study. Stop by our booth to discuss the latest data! For more details on our ASPN program, visit https://lnkd.in/gfPuXU7P American Society of Pain and Neuroscience ASPN #ChronicLowBackPain #LookForTheLigament #MildProcedure #VertosMedical #PainMedicine #LSS #ELEVATEwithmild
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Assistant Professor at the Center for Brain Science and Applications, School of Artificial Intelligence and Data Science, IIT Jodhpur
Our first independent work from the lab (by Avinash Ranjan) is published in Network Neuroscience now! Here is a short summary of the work: Question: Epileptic seizures are considered a dynamic disease of brain networks, representing a complex interplay between the organization of brain networks and the dynamics of metabolic resources. This interplay shapes how seizures initiate and spread in the brain. How do the structure of brain networks and the dynamics of resource allocation influence the generation and propagation of seizures? Impact: Understanding seizure dynamics at the whole-brain level is crucial for controlling abnormal hypersynchronous activity. Currently, complete brain coverage recordings are lacking in both patients and animal models. In this study, we investigate seizure dynamics at whole brain level in silico. Moreover, our results support existing studies that suggest the cortico-thalamic initiation of generalized seizures, with regions primarily in the cortex initiating the seizures.
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Cajal's Challenge - Almost 100 years ago, the father of modern neuroscience Santiago Ramón y Cajal, a Spanish physician, recognized that the injured brain could not repair or regrow damaged neurons. Cajal recognized that for individuals with devastating brain diseases or brain injuries, there was little that could be done to repair or regenerate neurons. He proposed that it was up to future scientists to solve the problem of regeneration. There lies Cajal’s Challenge. Read more at https://bit.ly/3xzQxZO #TBI #BrainRegeneration #BCI
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Reader in Artificial Intelligence for Healthcare - University of Hertfordshire - School of Physics, Engineering and Computer Science
Our MICCAI paper is among the top 11% of early-accepted submissions! I am very proud of this work, as I truly believe in the impact we can achieve with these generative AI models for medicine. MICCAI Society #GenerativeAI #brainMRI
I'm excited to announce that our paper, "Enhancing Spatiotemporal Disease Progression Models via Latent Diffusion and Prior Knowledge," has been early accepted and ranked among the top 11% of papers at MICCAI 2024, a top-tier conference in medical imaging. In this work, we introduce the Brain Latent Progression (BrLP), an innovative spatiotemporal model to predict future structural changes in the brains of individuals with neurological disorders via 3D brain MRI. The video below illustrates four case studies where BrLP predicts structural changes in subjects experiencing (1) mild cognitive impairments, (2) normal aging, and (3) Alzheimer's disease. In the fourth case study, we demonstrate the simulated progression of a single subject under these three distinct cognitive statuses. Key technical details: BrLP incorporates subject metadata, including demographic and potentially genetic factors. It leverages longitudinal data when available and integrates prior knowledge of disease progression to precisely predict changes across different brain regions. The model operates in a small latent space, significantly reducing the computational resources needed compared to running the progression in the 3D imaging space. Additionally, we introduce a technique called Latent Average Stabilization (LAS) to improve the spatiotemporal consistency of the predicted progression. Explore our preprint and access the code here: Arxiv preprint: https://lnkd.in/dWbUEyQs GitHub code: https://lnkd.in/d24B6JQ6 Authors: Lemuel Puglisi (University of Catania), Daniel Alexander (University College London), Daniele Ravì (University of Hertfordshire) #MICCAI #MICCAI2024
Case studies from Brain Latent Progression (BrLP) - MICCAI 2024
https://www.youtube.com/
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Veteran | Pilot | Biomedical Engineer | Neurorehabilitation Researcher & Consultant | Ambassador of Accessible Space Travel | Advocate for Functional Independence
Sharing this U2FP interview from my mentor Dr. Reggie Edgerton that speaks about our research with neuromodulation and overall approach towards spinal cord injuries (SCI). Dr. Edgerton has been my mentor since 2019, guiding me as both research participant and apprentice biomedical researcher. Together, we've explored approaches like transcutaneous spinal stimulation and intent-driven activity-based training, including robot-assisted gait training using the Ekso Bionics exoskeleton, among other modalities. By combining these methods, challenging the participant by gradually reducing the robot assistance of the exoskeleton and promoting intent-driven active participation, we've been able to demonstrate a novel learning phenomenon within the central nervous system (CNS) that’s allowed me to go from complete to incomplete SCI. These achievements have not only transformed my health but also enhanced my sensory awareness, proprioception, and physical abilities following a traumatic complete spinal cord injury and resulting paralysis. These efforts have not only enabled me to transition from complete to incomplete SCI, but also reverse and prevent almost all secondary complications associated with my paralysis. I feel incredibly blessed and excited to continue pushing the boundaries and exploring the endless possibilities to see just how far I can push my nervous system through self-experimentation to continue demonstrating that reversing complete paralysis is not only possible but achievable. #changethestandardofcare #demonstratingsolutions #reversingparalysis
Today we are talking to V. Reggie Edgerton, a Professor Emeritus of Nuerobiology at UCLA and co-founder of the spinal stimulation company, SpineX. Reggie Edgerton is a giant in the field of neuromodulation. Some have called him the father of spinal stimulation, and his influence can be found in the work of most researchers in that field today. Notable names such as Susan Harkema and Gregoire Courtine were actually students in Reggie’s lab before going on to achieve their successes. Reggie has been at this work for a while. His first paper on physiology was published in 1969 and it takes some effort to scroll through the sheer number of publications to his most recent work. During the conversation, Reggie reminds us that spinal cord injury involves an incredibly complex, multi-variable system that we still know very little about. He makes the case that our current research approach may be woefully oversimplified to be of much use. Reggie also speaks to the guiding principles of his work in desiring to find out what is possible. After so many years in the field, you will find in this conversation that Dr. Edgerton’s work is still being led by his curiosity. And you’ll hear just how holistic his approach is from the moment the conversation begins! Link: https://lnkd.in/gye8NRZP #sci #spinalcordinjury #paralysis #paralyzed #spinalcordresearch
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We continue to innovate
We are excited to announce the release of next-generation Intracept® Access Instruments purpose built for predictable and precise targeting of the basivertebral nerve in the treatment of #vertebrogenic pain. Learn how these new access instruments advance the proven, durable and safe #Intracept Procedure by reading today’s press release or by visiting us in Booth #201 at the American Society of Pain and Neuroscience ASPN #ASPNPAIN2023 Conference to see them firsthand: https://lnkd.in/g_zVS2Jw
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From personal experience, Quell is an amazing device. It is part of the growing field of what I refer to as transcutaneous neuromodulation devices. Quell has the potential to help countless individuals suffering from a variety of pain problems in general, with fibromyalgia among them. These devices in the class rely upon leveraging the body’s own pain reduction mechanism, the same parts of the pain pathway that medications influence to help reduce the transmission or perception of pain. These devices demonstrate clinical efficacy when used alone or to supplement typical standard of care medication treatment. With the low, or even lack of, a side effect profile, one can argue the need to be considered as a front-line treatment, or at least enhance the results of more traditional medication approaches. Hope more physicians and patients start to learn more about these devices like Quell.
Thank you to #ASPN and all who came by to discuss Quell Fibromyalgia. If you were unable to attend, learn more about Quell Fibromyalgia at https://bit.ly/3DlHfjJ Learn how to start prescribing Quell Fibromyalgia at https://bit.ly/3K7181D American Society of Pain and Neuroscience ASPN NeuroMetrix, Inc. Breck Harmel Nick Vanchina
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I'm excited to announce that our paper, "Enhancing Spatiotemporal Disease Progression Models via Latent Diffusion and Prior Knowledge," has been early accepted and ranked among the top 11% of papers at MICCAI 2024, a top-tier conference in medical imaging. In this work, we introduce the Brain Latent Progression (BrLP), an innovative spatiotemporal model to predict future structural changes in the brains of individuals with neurological disorders via 3D brain MRI. The video below illustrates four case studies where BrLP predicts structural changes in subjects experiencing (1) mild cognitive impairments, (2) normal aging, and (3) Alzheimer's disease. In the fourth case study, we demonstrate the simulated progression of a single subject under these three distinct cognitive statuses. Key technical details: BrLP incorporates subject metadata, including demographic and potentially genetic factors. It leverages longitudinal data when available and integrates prior knowledge of disease progression to precisely predict changes across different brain regions. The model operates in a small latent space, significantly reducing the computational resources needed compared to running the progression in the 3D imaging space. Additionally, we introduce a technique called Latent Average Stabilization (LAS) to improve the spatiotemporal consistency of the predicted progression. Explore our preprint and access the code here: Arxiv preprint: https://lnkd.in/dWbUEyQs GitHub code: https://lnkd.in/d24B6JQ6 Authors: Lemuel Puglisi (University of Catania), Daniel Alexander (University College London), Daniele Ravì (University of Hertfordshire) #MICCAI #MICCAI2024
Case studies from Brain Latent Progression (BrLP) - MICCAI 2024
https://www.youtube.com/
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Today we are talking to V. Reggie Edgerton, a Professor Emeritus of Nuerobiology at UCLA and co-founder of the spinal stimulation company, SpineX. Reggie Edgerton is a giant in the field of neuromodulation. Some have called him the father of spinal stimulation, and his influence can be found in the work of most researchers in that field today. Notable names such as Susan Harkema and Gregoire Courtine were actually students in Reggie’s lab before going on to achieve their successes. Reggie has been at this work for a while. His first paper on physiology was published in 1969 and it takes some effort to scroll through the sheer number of publications to his most recent work. During the conversation, Reggie reminds us that spinal cord injury involves an incredibly complex, multi-variable system that we still know very little about. He makes the case that our current research approach may be woefully oversimplified to be of much use. Reggie also speaks to the guiding principles of his work in desiring to find out what is possible. After so many years in the field, you will find in this conversation that Dr. Edgerton’s work is still being led by his curiosity. And you’ll hear just how holistic his approach is from the moment the conversation begins! Link: https://lnkd.in/gye8NRZP #sci #spinalcordinjury #paralysis #paralyzed #spinalcordresearch
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Have you ever wondered about the best placement of ECoG electrodes for BCI control? Mariana P Branco, Erik Aarnoutse, Nick Ramsey, Mariska van Steensel and I just published a systematic review in the European Journal of Neuroscience in which we investigated whether electrode placement above (epidural) or below the dura mater (subdural) influences signal quality and safety. (Very) long story short: even though subdural ECoG shows slightly higher signal quality, both epidural and subdural ECoG allow for stable and complex BCI control, and there does not seem to be a difference in the nature of reported complications. Find the link to the full-text article here (with graphical abstract by Malinda Verberne):
Nine decades of electrocorticography: A comparison between epidural and subdural recordings
onlinelibrary.wiley.com
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