HiFiBiO Therapeutics’ Post

Did you know you can read the digital version of ICE magazine online? Link below to read today!

Results from the FLAURA2 trial and the MARIPOSA trial have expanded options in metastatic EGFR-mutant NSCLC but also introduced important questions. https://bit.ly/3Ugxknx

CM77T, neoadj CHEMO + Nivo NSCLC up to stage IIIB Very interesting data on multi-station N2 stages, very clear DFS amplitude, the resectability of the T is therefore more important than the number of N2 stations! A paradigm shift underway! https://lnkd.in/e3ckeN3S

RCT For 46 with Radix

Exploring the optimal freeze time and passes of the 1.1mm cryoprobe in PPL-TBCB Key messages 1. 3 passes, 6 seconds freeze time with 1.1mm probe provide equivalent diagnostic yield to the conventional 1.9mm probe 2. Ultrathin cryoprobe allow access into deeper, smaller targets with shorter procedural time 3. The procedural setup and predictive factors for PPL-TBCB may potentially differ from ILD-TBCB which warrant further future research and standardisation Link to letter here: https://lnkd.in/g7wCDZY4

BREAKING: Utah set to legalize non-FDA approved placental cell therapies. “A health care provider whose scope of practice includes the use of stem cell therapy may perform a stem cell therapy that is not approved by the United States Food and Drug Administration.” A state-by-state adoption of medical marijuana legalization has overcome federal roadblocks to help millions of Americans. A state-by-state adoption of locally regulated regenerative medicine may do the same for healthcare. This is huge. https://lnkd.in/esjV_FNv

The #84th_ADA has ended. While #incretins were in the spotlight, we are thrilled to highlight the achievements of our #DA1726, an once weekly applicable #GLP1R_GCGR dual agonist with best-in-class potential. I applaud our dedicated researchers for their hard work in achieving positive experimental outcomes, which were presented in Orlando on a hot day. For those interested in #DA1726, which demonstrates impressive effects on reducing body fat and increasing lean body mass rate in obese mice, please refer to the poster file linked below. https://lnkd.in/dcTCqN24

⚽ Biochemical Response Comparisons of a Competitive Microcycle Vs. Congested Fixture Periods in Elite Level European Champions League Soccer Players The aim of this investigation was to analyses differences between post-game biochemical responses in congested (CP, when two consecutive games were played within 4 days or less) vs. non-congested (NCP, when two consecutive games were played within 5 days or more) periods. Assessment of creatine kinase (CK) and salivary cortisol (sCort) and immunoglobulin-A (sIgA) were performed across 12 separate training macrocycles of 14 competitive professional matches. The NCP analysis revealed significantly higher CK values from one day after match day (MD+1) than values found in MD and MD+2 (Effect size (ES): 0.82-1.13, p<0.0033). The CP analysis revealed no significant changes in CK values between MD, MD+1 and MD+2. Higher values on MD+2 in CP vs. NCP were also revealed (ES:0.27, p<0.05). No significant changes in sCort and sIgA were observed. Congested competitive periods induce significant biochemical changes revealed amongst elite soccer players that should influence their preparation and management. https://lnkd.in/g8xrRH6

Discovery of a novel series of GPR88 agonists based on the ‘reversed amide’ strategy. https://lnkd.in/eBuiPk7D

Labcorp’s disseminated NALM6-Luc-mCh-Puro ALL model in NSG mice, established by our teams in house, provides yet another tool for the preclinical development of therapies directed against B-cell malignancies. We have characterized the response to CD19-targeted CAR T cell treatment and evaluated the activity and persistence using flow cytometry with expanded Persistence T panels. Find out more: https://lnkd.in/g9_zqh4Q #AcuteLymphoblasticLeukemia #TumorModel #FlowCytometry