Artiva Biotherapeutics

Director, Bioinformatics and Data Science

Artiva Biotherapeutics San Diego, CA
Artiva Biotherapeutics

Director, Bioinformatics and Data Science

Artiva Biotherapeutics San Diego, CA
2 weeks ago 52 applicants

See who Artiva Biotherapeutics has hired for this role

About Artiva:
Artiva is clinical-stage biotechnology company focused on developing natural killer (NK) cell-based therapies for patients suffering from devastating autoimmune diseases and cancers.

Artiva’s lead product candidate, AlloNK, is a non-genetically modified, off-the-shelf, allogeneic, cryopreserved NK cell therapy designed to enhance the antibody-dependent cellular cytotoxicity (ADCC) effect of mAbs to drive B-cell depletion and to be administered in the community setting. Unlike CAR-T and any genetically modified cell therapy, AlloNK is a non-genetically modified NK cell therapy candidate and has not shown any secondary malignancies in our clinical trials, which is a benefit in an autoimmunity setting. Using the company’s proprietary cell therapy manufacturing platform, Artiva can generate thousands of doses of cryopreserved, infusion-ready AlloNK cells from a single cord blood unit. The FDA has granted Fast Track designation to AlloNK in combination with rituximab or obinutuzumab for the treatment of class III or IV lupus nephritis, and AlloNK in combination with rituximab for the treatment of relapsed or refractory non-Hodgkin lymphoma of B-cell origin (B-NHL).

AlloNK, is currently being evaluated in combination with B-cell targeted mAbs in

patients with autoimmune diseases and cancers, such as lupus nephritis, SLE, rheumatoid arthritis, pemphigus vulgaris, the ANCA-associated vasculitis subtypes GPA/MPA, and B-NHL. In addition, we are also pursuing AlloNK and our CAR-NK product candidates in multiple indications through collaborator-funded trials. Artiva’s cell therapy manufacturing platform incorporates cell expansion and activation technology developed by Artiva’s strategic partner, GC Cell Corporation, a member of the GC family of companies, a leading healthcare company in Korea.

Artiva is headquartered in San Diego and backed by leading venture investors including 5AM Ventures, RA Capital Management and venBio Partners.

For more information, visit www.artivabio.com.

Position Summary:
Reporting to the SVP, Research & Early Development, the Director, Bioinformatics and Data Science will establish the function at Artiva. The successful candidate will be responsible for implementation of the infrastructure and tools that are critical for enabling CMC, preclinical, translational, and clinical research objectives that will inform and accelerate development of our NK cell therapies in areas of unmet medical need.

Artiva is a clinical stage biotechnology company developing novel allogeneic NK cell therapies for application in autoimmune disease and cancer. The primary focus of this role is to develop the framework and computational tools to leverage data across research, drug development and manufacturing to translate insights into therapies. The ideal candidate will have a strong background in bioinformatics, AI/machine learning, and statistics with a proven track record of transforming complex biological data into actionable insights. A solid understanding of immunology is preferred.

Role & Responsibilities

  • Integrate the Bioinformatics and Data Science function within the larger organization to ensure maximal value is realized for data generated.
  • Provide bioinformatics and data science subject matter expertise in the planning and execution of NK cell therapy projects that require advanced analytics methods and cutting-edge data visualization tools.
  • Provide in-depth statistical and data analytical expertise across the organization by collaborating with Research, Translational Science, Clinical Development, and CMC.
  • Collaborate with bench scientists to develop experimental hypotheses and help design computational pipelines and data visualization capabilities.
  • Design and implement an end-to-end data repository to enable the use of analytical methods and machine learning techniques for pattern recognition and insight generation.
  • Implement innovative research projects internally, or with external resources, to improve products or processes.
  • Leverage clinical trial data, translational analytics, and skill in mining large data sets to further the current understanding of autoimmunity and/or immune-oncology mechanisms in disease.
  • Functional representation at project and leadership team meetings and external scientific meetings.

Experience, Education And Specialized Knowledge And Skills
Must thrive working in a fast-paced innovative environment while remaining flexible, proactive, resourceful and efficient. Excellent interpersonal skills, ability to develop important relationships with key stakeholders, conflict management and negotiation skills, ability to analyze complex issues to develop relevant and realistic plans and recommendations. Demonstrated ability to translate strategy into action. Excellent analytical skills, ability to communicate complex issues in a simple way, and ability to orchestrate plans to resolve issues and mitigate risks.

  • Ph.D. in Bioinformatics, Computational Biology, Computer Science, or related discipline with at least 10 years of relevant experience.
  • Demonstrated skills in programming languages such as Python and R.
  • Proficiency with machine learning frameworks.
  • Proven experience in designing and implementing large-scale data storage solutions.
  • Strong track record in algorithm development, preferably with applications in immunology, immune-oncology or personalized medicine.
  • Excellent communication skills, verbal and
  • Demonstrated ability to set goals, perform long-term project planning, budgeting, and operational excellence.
  • Ability to interact effectively across boundaries using influence and relationship building
  • Strong problem-solving capabilities with the ability to prioritize and make tradeoffs to achieve goals.

Competencies

  • Decision Making
  • Risk Management
  • Time Management
  • Business Planning
  • Strategic thinker
  • Implementing Plans
  • Operations Management Analysis & Reporting
  • Finance
  • Negotiation
  • Human Resources
  • Leadership & Team Development

Attributes

  • Honesty/Integrity
  • Communication skills
  • Self-starter
  • Forward thinking
  • Creative/imaginative
  • Confident
  • Self-controlled
  • Intuitive
  • Positive
  • Committed
  • Ambitious/driven
  • Agile
  • Collaborative
  • Transparent

In addition to a great culture, we offer:
  • A beautiful facility
  • An entrepreneurial, highly collaborative, and innovative environment
  • Comprehensive benefits, including:
  • Medical, Dental, and Vision
  • Group Life Insurance
  • Long Term Disability (LTD)
  • 401(k) Retirement Plan
  • Employee Assistance Program (EAP)
  • Flexible Spending Account (FSA)
  • Paid Time Off (PTO)
  • Company paid holidays, including the year-end holiday week
  • Our recognition program, Bonus.ly, is where you can trade in points earned for things you want.

If all this speaks to you, come join us on our journey!

Artiva Biotherapeutics is an equal employment opportunity employer.

Base Salary: $170,000 - $210,000 Exact compensation may vary based on position level, skills and experience.

  • Seniority level

    Mid-Senior level

  • Employment type

    Full-time

  • Job function

    Research, Analyst, and Information Technology

  • Industries

    Biotechnology Research and Pharmaceutical Manufacturing

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