CATUG

Better quality #RNA. Better #experiments. Explore the benefits of CatPure labeled #mRNA and order here: https://lnkd.in/eiuqm3_a #labeledRNA #research #egfp #celltherapy #genetherapy #transfection #qualitycontrol #qualityassurance

Adam Crowe (Cytiva) recently gave a wonderful #webinar on the correlation between lipid purity and mRNA lipidation. In particular, mRNA adducts can result due to the breakdown products of N-oxide impurities. The ionizable lipids used in LNPs are especially susceptible to forming N-oxide impurities. Cytiva is an equipment #partner of ours, and they supply terrific technical solutions and support for our various manufacturing projects. Check out this great article and webinar that delves into findings that make for better #mRNA drugs. https://lnkd.in/eA_Uv92C #LNP #LNPs #LipidNanoparticle #DDS #purification #RNA #pharmaceuticalmanufacturing #bioprocessing #biologics #celltherapy #genetherapy #biotechnology #molecularbiology

Targeted degradation has emerged as a powerful therapeutic modality. Relying on “event-driven” pharmacology, proteolysis targeting chimeras (PROTACs) can degrade targets and are superior to conventional inhibitors against undruggable proteins. Scientists from University of Pennsylvania present an engineered bioPROTAC template able to complex with cationic and ionizable lipids via electrostatic interactions for cytosolic delivery. When delivered by biocompatible lipid nanoparticles, these modified bioPROTACs can rapidly degrade intracellular proteins, exhibiting near-complete elimination (up to 95% clearance) of targets within hours of treatment. https://lnkd.in/eJkbu6KV #lipidnanoparticles #LNP #LNPs #DDS Controlled Release Society #CRS2024 #precisionmedicine #drugdeliverysystems #PROTACs #bioPROTAC

Michael J Mitchell et al. continue to innovate and impress with their new single step #LNP formulation technique ("click-like chemistry"). They have also found a way to lojack and track these particles to better target specific organs. "We've developed what we call an amidine-incorporated degradable (AID) lipid, a uniquely structured biodegradable molecule," Mitchell says. "Think of it as an easy-to-build custom mRNA vehicle with a body kit that informs its navigation system. By adjusting its shape and degradability, we can enhance mRNA delivery into cells in a safe manner. By adjusting the amount of the AID lipid that we incorporate into the LNP, we can also guide it to different organs in the body, much like programming different destinations into a GPS." Link to paper 👉 https://lnkd.in/en6jJaUS https://lnkd.in/ebgp66ny #lipidnanoparticles #LNPs #DDS #CRS Controlled Release Society #CRS2024 University of Pennsylvania #nanoparticles #mRNA #RNA #innovation #medicine #cancer #research #manufacturing #pharmaceuticalmanufacturing #PNP #molecularbiology #biology #chemistry #genetics #genetherapy #geneediting #celltherapy

Noubar Afeyan announced that Flagship Pioneering raised $3.6B in a new funding round. $2.6B will go to Flagship Pioneering Fund VIII, and $1B will be going to what it described as side funds and sector-specific strategic partnerships. One thing is for sure, big things for the #biotech and #biopharma companies that they choose to support. https://lnkd.in/e8yiTjyG #vc #fundraising #venturecapital #Boston #biotechnology #investments #startups #leanstartups

We are excited to announce our sponsorship of the Technical Session Vl Gene Delivery and Gene Editing ll taking place today from 3:30pm-5:30pm CET. Both Lin Jin and Cesare Di Nitto will be in attendance and eager to meet with you to discuss potential projects. Please reach out via LinkedIn or come find them at the session to learn about what it is we do. See you there! #rnasynthesis #lnp #genedelivery #geneediting #CRS2024

Michael J Mitchell et al. continue to innovate and impress with their new single step #LNP formulation technique ("click-like chemistry"). They have also found a way to lojack and track these particles to better target specific organs. "We've developed what we call an amidine-incorporated degradable (AID) lipid, a uniquely structured biodegradable molecule," Mitchell says. "Think of it as an easy-to-build custom mRNA vehicle with a body kit that informs its navigation system. By adjusting its shape and degradability, we can enhance mRNA delivery into cells in a safe manner. By adjusting the amount of the AID lipid that we incorporate into the LNP, we can also guide it to different organs in the body, much like programming different destinations into a GPS." Link to paper 👉 https://lnkd.in/en6jJaUS https://lnkd.in/ebgp66ny #lipidnanoparticles #LNPs #DDS #CRS Controlled Release Society #CRS2024 University of Pennsylvania #nanoparticles #mRNA #RNA #innovation #medicine #cancer #research #manufacturing #pharmaceuticalmanufacturing #PNP #molecularbiology #biology #chemistry #genetics #genetherapy #geneediting #celltherapy

Today wraps up day 2 at the CRS 2024 Annual Meeting & Expo. We had the privilege of attending a presentation delivered by Sergio Esteban Pérez, PhD. from Curapath on GMP-compliant LNP drug product, showcasing our very own CatPure™ Luciferase mRNA. Additionally, we were engaged by the enlightening session presented by Dario Neri and Willem Mulder on Plenary Duet: Nanomedicines, Antiboides and Imaging for Cancer Therapy, highlighting their profound insights on bridging academia and industry. We are eager to dive in to the poster session tomorrow with over 900 abstracts!

Curious about #mRNA #LNP critical quality attributes (CQAs) and regulatory requirements? Check this white paper from our partner Crystal Bio, a member of Crystal Pharmatech. CATUG-Crystal, a joint brand analytical lab based in US, is dedicated to deliver the best-in-class mRNA-LNPs analytical solutions to meet the evolving needs from our local clients. #Biopharmaceuticals #mRNA #LNP #QualityControl #CQAs #Analytical #NucleicAcidTherapeutics #Purity #Safety #Potency #ProductQuality #AnalyticalScience #Pharma #Biotech #CrystalBio #CATUG #Innovation

We have scalable options to manufacture your #LNP formulations at the development bench all the way up to cGMP commercial supply. For screening and small scale formulations, we utilize different Cytiva (formerly PNI) microfluidic mixing systems. As we scale up and further characterize your drug product, we can keep manufacturing #LNPs with the Cytiva #GMP skid, or we can transition to solvent injection. Our proprietary large-scale mixing system, #MaxMix, is capable of encapsulating batches with up to 100g of #mRNA (as seen in the image below). Check out the video for a complete listing of our capabilities. https://lnkd.in/eJNK78iK #lipidnanoparticles #nanoparticles #RNA #DDS #CRS Controlled Release Society #pharmaceuticalmanufacturing #pharma #biotech #biopharma