[WEBINAR] Analysis of Single-cell Multiome ATAC-Seq + Gene Expression. Why single-cell & multiomics? Intro to the 10X Genomics Multiome Assay, and "how to" analyze single-cell multiomics. https://bit.ly/4cGaEoO #singlecell #multiomics #epigenetics #bioinformatics #10x
Active Motif
Biotechnology Research
Carlsbad, California 7,379 followers
Enabling #Epigenetics #Genomics & #Transcriptomics Research!
About us
What is exciting about the area we work in Epigenomics is the systematic analysis of the global state of gene expression not attributable to mutational changes across the entire genome. Epigenetic mechanisms are affected by external factors including development in utero and in childhood, environmental chemicals, drugs and pharmaceuticals, aging, and diet. Changes to the epigenetic landscape can have a profound impact on health and disease. Precise mapping and measurement of the epigenetic landscape offers the promise of predictive biomarkers of disease development, even before changes in gene expression have taken place. Epigenomics is the “OME” connecting Genomics to Transcriptomics and Proteomics allowing a Multiomics approach to disease research which will result in a higher yield of data that can be aggregated and analyzed to become actionable information. What does Active Motif offer Epigenetic methods and approaches require the use of high-quality antibodies and enzymes that have undergone strict validation criteria. This allows the development of robust assays for use in mechanistic studies, translational medicine, drug discovery and diagnostics. Active Motif’s Product Development Program takes emerging novel techniques, and develops them into innovative products that allow researchers to perform the assays in their own labs as well as feeding into their end to end services pipeline. Active Motif is building a platform based on their patented transposase based technologies to simplify the interrogation of chromatin, the dynamics of histone modifications, chromatin remodeling, DNA methylation, transcription factor binding, as well as short and long range gene regulation by non-coding regulatory regions. Our bioinformatics platform can take the data generated by these techniques and provide powerful insights into the epigenetic changes occurring in disease or in response to drugs.
- Website
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http://www.activemotif.com
External link for Active Motif
- Industry
- Biotechnology Research
- Company size
- 51-200 employees
- Headquarters
- Carlsbad, California
- Type
- Privately Held
- Founded
- 1999
- Specialties
- Epigenetics, Genome wide epigenetic services, ChIP Seq, Transcription analysis, Histone antibodies, DNA methylation analysis, Gene regulation, Lab Services, Life Sciences, Laboratory Equipment, Transcriptomics, Recombinant Proteins, Longevity, Aging, Drug Discovery, ELISA Kits, Cell Biology, single cell , and multiome
Locations
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Primary
1914 Palomar Oaks Way
Carlsbad, California, US
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Avenue Reine Astrid 92
La Hulpe, Walloon Region 1310, BE
Employees at Active Motif
Updates
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[NEW Blog] Epigenetic Drug Screening in Patient-derived Organoids Identifies Potential Treatments for Aggressive Breast Cancer. Get caught up on this new research quickly with our informative overview by Dr. Stuart P. Atkinson! ➡ https://bit.ly/4cWzyA4 #cancerbiology #cancerresearch #organoids #drugdevelopment
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[NEW] Active Motif single-nucleus RNA-Seq (snRNA-Seq) enables analysis of retinal tissue in the quest to reverse age-related loss of vision! Great work out of the Dorota Skowronska-Krawczyk lab! https://lnkd.in/g9NjKmsP #RNASeq #RNA #Opthalmology #aging #lonvegity #epigenetics
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Active Motif's Epigenetic Services cited in this new research from the Stacey Glasgow lab at UC San Diego 👏 | Transcriptional regulation in #Neurobiology and #metabolism ➡ https://lnkd.in/gbGsT9A4
Spinal motor neuron development and metabolism are transcriptionally regulated by Nuclear Factor IA
biorxiv.org
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#Singlecell Services: ATAC-Seq, RNA-Seq, Multiomics | Active Motif is the ONLY 10x Genomics certified service provider for single-cell Multiome! Contact us to get started ➡ https://lnkd.in/gd-NMRYC
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Just published! PIXUL Multi-Sample Sonication applied to #proteomics in the workflow of this research team from South Africa - how do hepatitis B genotypes disregulate the Ras pathway and contibute to oncogenesis? https://lnkd.in/gTv7kP5E
Comparative Proteomic Analysis of Huh7 Cells Transfected with Sub-Saharan African Hepatitis B Virus (Sub)genotypes Reveals Potential Oncogenic Factors
mdpi.com
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[NEW] From DNA preparation to CUT&Tag and ChIP-Seq, a range of Active Motif reagents enabled this new work published in BioRxiv! Learn how the H2A.Z histone variant works with SRCAP (a Snf2 protein) to create a transcription axis ➡ https://lnkd.in/gqjn8KQZ
Mechanistic basis of gene regulation by SRCAP and H2A.Z
biorxiv.org
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Sortase enzymes are a key factor in bacteria anti-virulence screening. Get activity validated Sortase A5 and A2.9 in bulk for your assay development. https://lnkd.in/gE7kFCTf
Recombinant Sortase A5 protein
activemotif.com
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[NEW Podcast] In this episode we talked with Dr. James Hackett from EMBL in Rome about his work on epigenetic mechanisms in genome regulation and developmental programming. https://lnkd.in/eGttpFzg
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Active Motif reposted this
[NEW] Our look at a charismatic study by Edwin Neumann and Tessa Bertozzi - the CHARM effector "enchants" the endogenous DNA methylation machinery of neurons to silence prion gene expression & stop prion-associated neurodegeneration in its tracks! 🪄https://bit.ly/4cUvnVJ
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